To: All Persons or Entities who purchased Shire plc (“Shire” or the “Company”) (NASDAQGS: SHPG) stock prior to May 8, 2018. You are hereby notified that Levi & Korsinsky, LLP has commenced an investigation into the fairness of the Shire merger. Shire will be sold to Takeda Pharmaceutical Company Limited. Under the terms of the transaction, Shire shareholders will receive $30.33 in cash and either 0.839 Takeda shares or 1.678 Takeda American Depositary Shares for each share of Shire they own. To learn more about the SHPG merger and your rights, go to: http://www.zlk.com/mna/shire-plc or contact Joseph E. Levi, Esq. either via email at jlevi@levikorsinsky.com or by telephone at (212) 363-7500, toll-free: (877) 363-5972. There is no cost or obligation to you.

The investigation concerns whether the Board of Shire breached their fiduciary duties to stockholders by failing to adequately shop the Company before agreeing to enter into this transaction, and whether Takeda Pharmaceutical Company Limited is underpaying for Shire shares, thus unlawfully harming Shire shareholders.

Levi & Korsinsky is a national firm with offices in New York, Connecticut, California, and Washington D.C. The firm’s attorneys have extensive expertise in prosecuting securities litigation involving financial fraud, representing investors throughout the nation in securities lawsuits and have recovered hundreds of millions of dollars for aggrieved shareholders. For more information, please feel free to contact any of the attorneys listed below. Attorney advertising. Prior results do not guarantee similar outcomes.